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    11 The risk was increased to 3.5-fold in nulliparous women.The current language in the proposed chapter includes the word “shall,” meaning required, and “should,” meaning strongly recommended.The chapter will be useful in addressing the following in relation to HDs: Hazardous drug definition and risks A HD is defined as any chemical that is a health hazard, including those considered to be carcinogens, teratogens, reproductive toxins, genotoxins, irritants, corrosives, sensitizers, and/or agents that produce target organ effects.2,3 While the proposed chapter does not contain a list of HDs, they refer to The National Institute for Occupational Safety and Health (NIOSH) list of HDs which is updated periodically.10 Drugs that are classified as chemotherapy, antivirals, hormones, and immunosuppressants are commonly considered hazardous. How should beyond-use-dates for compounded preparations be determined?Is intravenous ketamine useful for the treatment of major depressive disorder?

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